Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
CA 2376299 C · Owner: Green, Larry L. · Inventors: Green, Larry L.; Davis, C. Geoffrey; Ivanov, Vladimir E.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exons encoding the desired heavy chain isotype operably linked to switch segments , from a constant region of a different heavy chain isotype i.e. a non-cognate , switch region. Said additional constant region segment comprises a switch region and human constant region coding segment wherein the constant region , coding segment is operably linked to a switch region that is not normally associated …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 8, 2000 and granted November 1, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 8, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 8, 2022.
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Timeline
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.