Synthetic methods for preparing procyanidin oligomers
CA 2369799 A1 · Owner: Mars, Incorporated · Inventors: Basak, Amit; Romanczyk, Leo J. Jr.; Townsend, Craig A.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Processes are disclosed for the production of linear and branched procyanidin oligomers having "n" procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially protected (4~8) dimer. The dimer is optionally blocked, coupled with an activated protected monomer to produce a partially protected, optionally blocked trimer, and deprotected. The steps can be repeated to produce higher oligomers. Processes are also provided for producing (8~8), (8~6), and (6~6) dimers and doubly branched oligomers. Crystalline 8-bromo tetra-O-benzyl (-)-epicatechin is produced under certain conditions.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 29, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 29, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 29, 2022.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.