Use of selective antagonists of the .alpha.1b-adrenergic receptor for improvement of sexual dysfunction

Abstract From the Canadian patent

Compounds (I) (A=2-furyl, substituted 2-furyl 2-tetrahydrofuryl, substituted , alkoxy or substituted phenoxyalkyl; B=B1 B2 or B3, but if B=B1 then , A=substituted phenoxyalkyl) and their enantiomers diastereoisomers and , pharmaceutically acceptable salts are useful for the preparation of a medicament for the treatment of sexual dysfunction in males and females. Compounds II (I:B=B3, A ≠ 2-furyl) are novel and are claimed per se. Pharmaceutical compositions containing compounds II are also claimed as are , pharmaceutical compositions containing compounds I and one or more of a prostaglandin, a direct vasodilator and a 5 cGMP phosphodiesterase inhibitor (e.g. sildenafil). Compounds …