Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists
CA 2365391 A1 · Owner: Crain, Stanley M. · Inventors: Fleischner, Gerald M.; Shen, Ke-Fei; Crain, Stanley M.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
This invention relates to a method for treating a subject with irritable bowel syndrome ("IBS") which comprises long-term administration of an opioid receptor antagonist at an appropriately low dose which will selectively antagonize excitatory opioid receptor functions, but not inhibitory opioid receptor functions in myenteric neurons , in the intestinal tract as well as in neurons of the central nervous system ("CNS"). The administration of the opioid receptor antagonist at a low dose enhances the potency of the inhibitory effects of endogenous opioid peptides present in the intestinal tract and the CNS thereby reducing abdominal pain and stool frequency resulting from abnormally …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 2, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 2, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 2, 2022.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.