Vaccines and gene therapy compositions and methods of making and using the same

Abstract From the Canadian patent

Methods of inducing an immune response against an immunogen in an individual are disclosed. The methods comprise administering to the individual one or , more nucleic acid molecules that comprise a nucleotide sequence that encodes an immunogen and a nucleotide sequence that encodes a Major Histocompatibility Complex antigen. The nucleotide sequences that encode the immunogen and Major Histocompatibility Complex antigen are expressed when taken up by cells of the individual and an immune response against the immunogen is induced in the individual. Methods of reducing rejection of unmatched donor cells tissue or , organ in an individual undergoing cell tissue or organ transplantation …