Nitroreductase enzymes
CA 2362523 A1 · Owner: Health Protection Agency · Inventors: Minton, Nigel; Anlezark, Gill; Vaughan, Thomas
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to polypeptides and proteins having nitroreductase activity. The invention also relates to DNA and genes encoding these nitroreductases, and to methods of obtaining such enzymes DNA and , genes. In a particularly preferred aspect the nitroreductase enzymes , demonstrate preferential catalytic conversion of the alkylating agent CB1954 into its highly cytotoxic 4-hydroxylamine (4HX) derivative this derivative , demonstrating anticarcinoma properties. Accordingly the catalytic activity of , the nitroreductase enzymes of the present invention may be employed to achieve catalysis of CB1954 into its cytotoxic derivative in a site-directed manner such as by …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed February 10, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended February 10, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by February 10, 2022.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.