Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels
CA 2361806 C · Owner: Muller, George W. · Inventors: Stirling, David; Muller, George W.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
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1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. Thus in one aspect, the invention provides a compound of the formula:, (see formula I) , in which: the carbon atom designated C* constitutes a center of chirality when n is not zero and when R1 is not R2; one of X1 and X2 is nitro, alkyl of one to six carbons or , NH-Z, and the other of X1 or X2 is hydrogen; each of R1 and R2 independent of the other, is hydroxy or NH-Z; R3 is hydrogen alkyl of one to six carbons, or halo; Z is hydrogen aryl, an acyl of one to six carbons, or an alkyl of one to six carbons; and n has a …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 17, 2000 and granted March 13, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended March 17, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 17, 2022.
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