Clonal expansion of t cells of unknown specificity and identification of ligand recognized by the clonally expanded t cells
CA 2357484 C · Owner: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute · Inventors: Matsushita, Sho; Nakashima, Toshihiro
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention is directed to a process for clonally expanding T cells of unknown specificity which comprises co-culturing said T cells of unknown specificity with combinatorial randomized peptide library Xn, an , interleukin, and MHC class II antigen-expressing cells with DNA synthesis being suspended, said cells being derived from the individual where said T cells are obtained and , optionally in the presence of anti-CD29 antibody having an agonist activity. A process for identifying a peptide ligand recognized by said T cell clone of unknown specificity is also provided.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 19, 2001 and granted December 13, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended September 19, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 19, 2023.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.