Preparation and uses of conjugated solid supports for boronic acids

Abstract From the Canadian patent

The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and, dihydroxyalkylaminobenzyl groups and methods for making and using them. The supports are, particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid, phase synthesis such as those used in combinatorial chemistries. The compositions and methods, of the invention are also useful as scavenger solid supports e.g. in , solution-phase parallel, synthesis of small molecule libraries and for use in resin-to-resin transfer reactions via phase, transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The, methods of the invention provide …