1,2-annelated quinoline derivatives

Abstract From the Canadian patent

This invention concerns , compounds of formula (I), the pharmaceutically , acceptable acid addition salts and the stereochemically , isomeric forms thereof wherein -X1-X2-X3- is a , trivalent radical; >Y1-Y2- is a trivalent radical; r and s are each independently , 0, 1, 2, 3, 4 or 5; t is 0 1, 2 or 3; each R1 and R2, are independently hydroxy halo, cyano, C1-6alkyl, trihalomethyl, trihalomethoxy C2-6alkenyl, C1-6alkyloxy, hydroxyC1-6alkyloxy C1-6alkylthio, C1-6alkyloxyC1-6alkyloxy C1-4alkyloxycarbonyl, aminoC1-, 6alkyloxy mono- or di(C1-6alkyl)amino, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, aryl, arylC1-6alkyl aryloxy or arylC1-, 6alkyloxy, hydroxycarbonyl C1-6alkyloxycarbonyl; or two …