Template-dependent ligation with pna-dna chimeric probes
CA 2353801 A1 · Owner: Applera Corporation · Inventors: Chen, Caifu; Egholm, Michael
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention provides methods, kits, and compositions for ligation of PNA-DNA chimeric probes and oligonu-, cleotides when they are hybridized adjacently to template nucleic acids and ligation reagents. Structural requirements of the chimeras for ligation include 5 to 15 contiguous PNA monomer units 2 , or more contiguous nucleotides, and a 3' hydroxy or 5' hydroxyl terminus. The chimera and/or oligonucleotide may be labelled with fluorescent dyes or other labels. The methods include, for example, oligonucleotide-ligation assays (OLA) and single nucleotide polymorphism detection.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 6, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 6, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 6, 2022.
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Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.