An improved method for the production and purification of adenoviral vectors
CA 2353787 C · Owner: Cho, Toohyon · Inventors: Zhang, Shuyuan; Wu, Zheng; Cho, Toohyon
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular it has been , demonstrated that for adenovirus the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions and in particular in serum-free , suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed November 16, 1999 and granted December 20, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended November 16, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by November 16, 2021.
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Timeline
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.