Bioassay for identifying estrogen receptor-.beta./.alpha. selective modulators
CA 2352203 A1 · Owner: Bhat, Ramesh A. · Inventors: Bhat, Ramesh A.; Harris, Heather
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides novel assay methods for identifying compounds that selectively activate estrogen receptors (ER) of the alpha or beta subtype. In particular, the results from two assays one measuring ER-.beta. , activity and the other measuring ER-.alpha. activity are interpreted. The assay measuring ER-.beta. activity uses cells comprising endogenous metallothionein-II as well as a DNA plasmid comprising a polynucleotide encoding human ER-.beta.. The assay monitors expression of metallothionein-IImRNA in said cells, wherein the level of metallothionein-II expression is regulated when a potential ligand binds to ER-.beta.. The assay measuring ER- .alpha. activity uses …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 17, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 17, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 17, 2021.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.