Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group

Abstract From the Canadian patent

Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms heterocycloalkyl of 3 to 10 carbon , members aryl, heteroaryl, halogen, CN, NO2, CO2R6 COR6, OR6, SR6, SOR6, SO2R6, CONR7R8, NR6N(R7R8) N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4 taken together form a 3 , to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms perhaloalkyl of 1 to 6 , carbon atoms, or aryl; R8 is …