Methylated cpg island amplification (mca)
CA 2350085 A1 · Owner: Issa, Jean-Pierre · Inventors: Toyota, Minoru; Baylin, Stephen; Issa, Jean-Pierre
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method is provided for identifying a methylated CpG containing nucleic acid including contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated CpG sites contacting the sample with , an isoschizomer of the methylation sensitive restriction endonuclease wherein , the isoschizomer cleaves both methylated and unmethylated CpG sites. The method also includes adding an oligonucleotide under conditions and for a time to allow ligation of the oligonucleotide to nucleic acid cleaved by the restriction endonuclease, and amplifying the nucleic acid. A method is also provided for detecting an age associated disorder including contacting a …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed November 2, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended November 2, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by November 2, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.