Stimulation of angiogenesis via syndecan-4 cytoplasmic domain signaling pathway
CA 2349720 A1 · Owner: Horowitz, Arie · Inventors: Horowitz, Arie; Simons, Michael
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a methodology and compositions for stimulating angiogenesis in-situ within viable cells tissues and organs comprising , endothelial cells. The methodology focuses upon and controls the phosphorylation of the 183rd amino acid residue serine within the cytoplasmic , domain and intracellular tail of transmembrane syndecan-4 proteoglycans which are then positioned at and through the cellular membrane of viable endothelial cells. By intervening and maintaining the 183rd residue in a nonphosphorylated state, a consequential cascade of intracellular events is initiated which result in a stimulation of angiogenesis in-situ.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed November 10, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended November 10, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by November 10, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.