Engraftable human neural stem cells

Abstract From the Canadian patent

Stable clones of neural stem cells (NSCs) have been isolated from human fetal telencephalon. In vitro, these self-renewing clones can spontaneously give rise to all three fundamental neural cell types (neurons oligodendrocytes and , astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, these NSCs, like their rodent counterparts can participate in aspects of normal development. These include migration along well-established migratory pathways to disseminated CNS regions differentiation into developmentally and regionally appropriate cell types in response to microenvironmental cues and non-disruptive non-tumorigenic , interspersion with host …