Sesterterpene derivatives exhibiting antifungal activities

Abstract From the Canadian patent

Compounds represented by general formula (I); and pharmaceutically acceptable salts or esters thereof, (wherein Y1 is oxygen NH, O-CO, O-SO2, O-CO-NH, O-CS-, NH, NH-CO NH-SO2, NH-CO-NH or NH-CS-NH; and R1 is alkyl alkenyl, alkynyl, aryl, aralkyl, arylalkenyl arylalkynyl, cycloalkyl, cycloalkylalkyl alkylcarbonyl, alkoxycarbonyl, arylcarbonyl or a heterocyclic group provided , these groups may be optionally substituted). The above compounds salts and , esters exert excellent antifungal effects on fungi against which the existing antifungal agents are not sufficiently efficacious thus being useful as , antifungal agents.