Treatment of hyperproliferative disorders

Abstract From the Canadian patent

A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject in combination, a treatment effective amount of: (a) a ceramide-generating retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) ceramide degredation inhibitor, such as compounds selected from the group consisting of (i) glucosylceramide synthesis inhibitors (ii) , sphingosine-1-phosphate synthesis inhibitors and (iii) protein , kinase C inhibitors. A preferred glucosyl ceramide synthesis inhibitor is 1phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred …