Cationic amphiphile micellar complexes

Abstract From the Canadian patent

The effective introduction of foreign genes and other biologically active molecules into targeted mammalian cells is a challenge still facing those skilled in the art. Gene therapy, for example requires successful , transfection of target cells in a patient. The present invention relates to novel micellar complexes of cationic amphiphilic compounds that facilitate delivery of biologically active molecules to the targeted cells of a mammal. The novel micellar complexes are comprised of a cationic amphiphile a , biologically active molecule, a derivative of polyethylene glycol (PEG) and , optionally, a co-lipid. A further aspect of the invention is the use of targeting absents in any of …