Pyrazinone protease inhibitors
CA 2334679 C · Owner: Markotan, Thomas P. · Inventors: Lu, Tianbao; Tomczuk, Bruce E.; Markotan, Thomas P.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Pyrazinone compounds are described, including compounds of Formula (I) wherein X is O, NR11 or CH=N, R3-R11, Ra Rb, Rc, W, m and n are set forth in , the specification as well as hydrates, solvates or pharmaceutically acceptable salts thereof. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases such as chymotrypsin, trypsin, thrombin plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. Compositions for inhibiting loss of blood platelets inhibiting formation of , blood platelet aggregates inhibiting formation of fibrin, inhibiting thrombus formation, and …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 11, 1999 and granted October 23, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 11, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 11, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.