Carboxamide compounds, compositions, and methods for inhibiting parp activity

Abstract From the Canadian patent

A compound of formula (I) or a pharmaceutically acceptable salt hydrate, ester, solvate, prodrug, metabolite stereoisomer, or mixtures thereof; , wherein: Y represents the atoms necessary to form a fused 5-to 6-membered aromatic or non-aromatic, carbocyclic or N-containing heterocyclic ring wherein Y and any heteroatom(s) therein are unsubstituted or independently substituted by at least one non-interfering alkyl alkenyl, cycloalkyl, cycloalkenyl, aralkyl aryl, carboxy or halo substituent; X is at the 1position of ring Y and is -COOR5 or a substituted or unsubstituted moiety selected from the group consisting of (a) (b), (c), (d), (e), (f) and (g) , wherein R7 is hydrogen alkyl, alkenyl, …