Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids

Abstract From the Canadian patent

Disclosed is the surprising discovery that aminophospholipids such as , phosphatidylserine and phosphatidylethanolamine are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibodytherapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided as are methods of specifically , delivering therapeutic agents including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels thereby , inducing thrombosis, necrosis and tumor regression.