Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

Abstract From the Canadian patent

This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof wherein A and R1 are each an , optionally substituted 5 to 6-membered heteroaryl wherein the heteroaryl is optionally , fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino, or an alkyl amino; R3 and R4 are each hydrogen halo, (C1-C4)alkyl optionally , substituted with halo and the like; and X1 to X4 are each hydrogen halo, hydroxy, (C1-C4)alkyl , optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus, useful for treating or preventing inflammation or other COX-2 related diseases.