Methods and compounds for modulating nuclear receptor coactivator binding
CA 2323575 A1 · Owner: Kushner, Peter J. · Inventors: Feng, Weijun; Wagner, Richard L.; Darimont, Beatrice
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to these sites. The methods can be applied to …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 30, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 30, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 30, 2021.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.