Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof
CA 2321119 A1 · Owner: Dana-Farber Cancer Institute, Inc. · Inventors: Makrigiorgos, G. Mike
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present application discloses a method of identifying mutations in a target DNA sequence. The method involves: (a) hybridizing the target DNA sequence with a control DNA sequence wherein said control DNA sequence is the wild-type DNA sequence corresponding to the target DNA sequence to create a duplex; (b) treating the duplex to remove any spontaneous aldehydes; (c) reacting the duplex with a repair glycosylase to convert any mismatched sites in the duplex to reactive sites containing an aldehyde-containing abasic site; (d) reacting the duplex with a compound of the formula X-Z-Y wherein X is a , detectable moiety, Y is NHNH2 O-NH2 or NH2, and Z is a hydrocarbon, alkylhydroxy …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed February 23, 1999. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended February 23, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by February 23, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.