Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure
CA 2316401 A1 · Owner: Baldwin, Jack Edward · Inventors: Terwisscha Van Scheltinga, Anke S.; Valegard, Karin; Ramaswamy, Subramanlan
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Three-dimensional crystal structure(s) of deacetoxycephalosporin C synthase (DAOCS) are described. The X-ray co-ordinates provide precise 3-dimensional information of amino acids within the structure of DAOCS. Some of these are in complexes with iron and/or substrates. Information from the structures is used to modify enzymes of the cephalosporin biosynthesis pathway including DAOCS deacetylcephalosporin C synthase DAOC/DACS such that they accept unnatural , substrates (e.g. penicillins G V) in order to improve the production of betalactam antibiotics. The structures may be used to predict the structures of other 2-oxoglutarate dependent enzymes thereby allowing the design of , …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 24, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 24, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 24, 2020.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.