Peptide chelators that predominately form a single stereoisomeric species upon coordination to a metal center

Abstract From the Canadian patent

The labeling of biologically important molecules via a bifunctional chelator can result in the formation of isomers or multiple species which can have , significant impact on the biological properties of the radiopharmaceutical. For receptor-based radiopharmaceuticals the target uptake is largely , dependent on the receptor binding affinity of the targeting molecule and the blood clearance of the labeled molecule which is determined by the physical , properties of both the targeting molecule and the metal chelate. Hence the , presence of isomers for the metal chelate can have significant impact on the radiopharmaceutical. Therefore, in the development of a radiopharmaceutical or …