Engraftable neural progenitor and stem cells for brain tumor therapy

Abstract From the Canadian patent

One of the impediments to the treatment of some human brain tumors (e.g. gliomas) has been the degree to which they expand migrate widely, and , infiltrate normal tissue. We demonstrate that a clone of multipotent neural progenitor stem cells, when implanted into an experimental glioma will , migrate along with and distribute themselves throughout the tumor in juxtaposition to widely expanding and aggressively advancing tumor cells while continuing to express a foreign reporter gene. Furthermore drawn , somewhat by the degenerative environment created just beyond the infiltrating tumor edge, the neural progenitor cells migrate slightly beyond and surround the invading tumor border. When …