Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
CA 2311969 A1 · Owner: Siedem, Colleen · Inventors: Tomczuk, Bruce E.; Siedem, Colleen; Lu, Tianbao
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Aminoguanidine and alkoxyguanidine compounds are described including , compounds of Formula (VII) wherein X is O or NR9 and Het, R1, R7, R8 R12-, R15, Ra, Rb, Rc, Z, and n are set forth in the specification as well as , hydrates, solvates or pharmaceutically acceptable salts thereof that inhibit , proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases such as chymotrypsin, trypsin, thrombin plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed November 25, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended November 25, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by November 25, 2020.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.