Modifying double stranded dna to enhance separations by matched ion polynucleotide chromatography
CA 2309760 A1 · Owner: Taylor, Paul D. · Inventors: Haefele, Robert M.; Gjerde, Douglas T.; Taylor, Paul D.
Overview
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Covalently bound non-polar tags are used to increase the retention times of double stranded polynucleotides on Matched Ion Polynucleotide Chromatography (MIPC) columns. In doing so, separations of DNA mixture components is improved. Additionally, when the non-polar tags are fluorophores detection , limits are also greatly reduced. Strategically tagged primers are used in conduction with PCR to produce DNA fragments having specifically tagged strands. This improves mutation detection by MIPC in several ways. Separations are improved, detection sensitivity is enhanced and non-stoichiometric , addition of wild type DNA prior to hybridization is now possible since only tagged fragments …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
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- Filed October 9, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 9, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 9, 2020.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.