Expression plasmids for multiepitope nucleic acid-based vaccines

Abstract From the Canadian patent

Improved plasmids and methods for nucleic acid-based vaccines. The use of epitopes, small immunologically relevant protein sequences that are capable of inducing both cellular and humoral responses that result in a protective or therapeutic immune response against large and complex pathogens for incorporation into nucleic acid-based vaccines. The structures and characteristics of gene expression systems that are capable of expressing multiple epitopes. A method of genetic immunization comprising the step of presenting multiple epitopes to an organism in need of said immunization. A plasmid for expression of multiple epitopes comprising a nucleic acid sequence encoding multiple …