Urea derivatives and their use as integrin inhibitors

Abstract From the Canadian patent

Compounds of formula (II) where R1 is in the para or meta position and is (A); R2 and R3 are each independently selected from hydrogen nitro, C1-6alkyl, C3-, 6cycloalkyl, C2-6alkenyl C2-6alkynyl, C1-4alkoxyl, C1-6alkylamino C1-, 6dialkylamino, C1-6alkylC1-4alkoxyl C1-6alkylaminoC1-6alkyl, amino, cyano, halogeno trifluoromethyl, -CO2R12 and -CONR12R13 where R12 and R13 are , independently selected from hydrogen or C1-6alkyl or R2 and R3 together with , the phenyl to which they are attached form a 9 or 10 membered bicyclic ring system; R4 is C1-4alkyl; R5 is selected from hydrogen and C1-4alkyl; R6 is selected from C1-6alkyl, C1-4alkyl(C4-6)cycloalkyl C1-6alkyl(C1-6)alkoxyl, C1-, …