Sarcodictyin and eleutherobin useful for stabilising microtubules
CA 2308327 A1 · Owner: Ohshima, Takashi · Inventors: Xu, Jin-You; Vandelft, Floris; Vourloumis, Dionisios
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Sarcodictyin A and B, eleutherobin, and bioactive analogs (A) thereof synthesized using solid phase and solution phase chemistries. The synthetic method employs an attachment of common precursors e.g. compounds 1880 or , 200, on a solid support for generating conjugates 230 and 240 followed by , standard chemical manipulations. A combinatorial library of sarcodictyins and eleutherobin analogs is constructed with modified C-8 ester C-15 ester and C-, 4 ketal functionalities and is screened for activity with respect to tubulin polymerization and cytotoxic activity against tumor cells including Taxol-, resistant lines. Compounds 600 610, 630, 660-700, 730, 760, 850, and 920 are identified …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 22, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 22, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 22, 2020.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.