Method for high resolution liquid chromatographic separation of polynucleotides
CA 2308314 A1 · Owner: Transgenomic, Inc. · Inventors: Haefele, Robert M.; Gjerde, Douglas T.; Taylor, Paul D.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Mixtures of dsDNA fragments are separated by Matched Ion Polynucleotide Chromatography (MIPC) using an isocratic mobile phase to elute polynucleic acid from an MIPC column. The use of isocratic elution conditions provides a marked improvement in the separation of dsDNA fragments compared to gradient elution conditions. Isocratic elution can also be used to effect an improved separation of heteroduplex and homoduplex mixtures when the chromatography is performed under partially denaturing conditions. In addition dsDNA fragments , are bound to the stationary phase under isocratic conditions until a solvent concentration is reached which releases fragments of a particular base pair …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 30, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 30, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 30, 2020.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.