Process for converting 9-dihydro-13-acetylbaccatin iii into taxol and derivatives thereof
CA 2307548 C · Owner: Ivax Laboratories, Inc. · Inventors: Liu, Jian
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A process for the preparation of taxol analogs thereof and their , intermediates is described. The process includes the steps of protecting the C- 7 hydroxy group of 9-dihydro-13-acetylbaccatin III with a suitable protecting group; oxidizing the C-9 hydroxy group; and adding a suitable side chain to the C-13 position. The intermediates include a compound having formula (1) wherein R is selected from the group consisting of benzyl substituted benzyl, benzylformate, substituted benzylformate tosyl, substituted tosyl, dihydropyran methoxymethyl, benzoyl and substituted benzoyl.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 1, 1998 and granted July 17, 2001. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 1, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 1, 2020.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.