Novel modified nucleic acid sequences and methods for increasing mrna levels and protein expression in cell systems
CA 2306799 A1 · Owner: Chen, Li How · Inventors: Meade, Harry; Chen, Li How
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of proteins which are known to be, or are likely to be difficult to express in , cell culture systems mammalian cell culture systems, or in transgenic animals. The preferred "difficult" protein candidates for expression using the recombinant techniques of the invention are those proteins derived from heterologous cells preferably those of lower organisms such as parasites bacteria, and virus, having DNA coding sequences comprising high overall AT content or AT rich regions and/or mRNA instability motifs and/or rare codons relative to …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 20, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 20, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 20, 2020.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.