Mutants of thyroid stimulating hormone and methods based thereon
CA 2302993 A1 · Owner: Szkudlinski, Mariusz W. · Inventors: Szkudlinski, Mariusz W.; Weintraub, Bruce D.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention is based upon the discovery that mutant .alpha. subunits and mutant .beta. subunits each comprising amino acid substitutions relative to the wild type can be produced and assembled to form a mutant TSH heterodimer or TSH analog that possesses higher bioactivity in vitro and longer half life in vivo. Accordingly, the present invention provides methods for using mutant TSH heterodimers, TSH analogs fragments, and derivatives , thereof for treating or preventing diseases of the thyroid in particular , thyroid cancer. The invention also relates to methods of diagnosis prognosis , and monitoring for thyroid-related functions. Pharmaceutical and diagnostic …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 22, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended September 22, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 22, 2020.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.