Ureido and thioureido derivatives of 4-amino-2(5h)-furanones and 4-amino-2(5h)-thiophenones as antitumor agents

Abstract From the Canadian patent

Subject of the present invention are compounds of general formula (I) wherein , A is oxygen or sulfur; X is oxygen or sulfur; R1 and R2 are independently hydrogen or an alkyl group with from 1 to 6 carbon atoms; R is selected from alkyl, cycloalkyl, alkylsulphinyl, alkylsulphonyl hydroxyalkyl, napthtyl, phenyl group which can be unsubsituted or substituted; or R is a 5- or 6membered heterocycle containing from 1 to 3 heteroatoms selected from oxygen sulfur and nitrogen, which can be optionally benzocondensed the pure , steroisomers or mixtures thereof as well as salts thereof with pharmaceutically acceptable acids or bases for the use as medicaments, in , particular as antitumor agents.