Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules

Abstract From the Canadian patent

The present invention relates to immunologically active molecules comprising an epitope of interest, more than one major histocompatibility complex class II element and an immunoglobulin constant , region element wherein the epitope is comprised in a fusion protein which comprises a major histocompatibility class II element wherein , each major histocompatibility class II element comprises two non-covalently associated chains comprising extracellular domains of a major histocompatibility complex class II protein and wherein the , major histocompatibility class II elements are covalently joined by one or more disulfide linkages present in the immunoglobulin constant region element. …