Phosphonic acid naphthylureas and their antiantiogenic and antitumorigenic use
CA 2297900 A1 · Owner: Gagliardi, Antonio R. · Inventors: Gagliardi, Antonio R.; Collins, Delwood C.; Nickel, Peter
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Novel phosphonic acid agents are synthesized and characterized and their pharmaceutical compositions provided. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown. Embodiments of the phosphonic acid agents include: (P-Yn1)m1-Q1-K-(Q2- (Yn2-P)m2)j wherein P is a phosphonic group or a phosphonic salt Y is -OCO-, -, NR1CO- or CON(R1)R2-; R1 is H CH2CO2H, or substituted or unsubstituted alkyl; R2 is substituted alkyl, aryl or arylalkyl; Q1 and Q2 are substituted or unsubstituted aryl groups; K is H, -NH-CO-NH- -NH-CS-NH-, -NHCO-R3-CONH- or -, NHCS-R3-CSNH-; provided when K is H R3 is a substituted or unsubstituted aryl …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed July 24, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended July 24, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by July 24, 2020.
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Timeline
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Sources & verification
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.