Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
CA 2293611 A1 · Owner: Georgiou, George · Inventors: Swartz, James R.; Qiu, Ji; Georgiou, George
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Disclosed are methods and compositions for producing heterologous disulfide bond containing polypeptides in bacterial cells. In preferred embodiments the , methods involve co-expression of a prokaryotic disulfide isomerase such as , DsbC or DsbG and a gene encoding a recombinant eukaryotic polypeptide. Exemplary polypeptides disclosed include tissue plasminogen activator.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 9, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended June 9, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 9, 2020.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.