Pgc-1, a novel brown fat ppar.gamma. coactivator

Abstract From the Canadian patent

The invention provides isolated nucleic acids molecules designated PGC-1 , nucleic acid molecules which encode proteins which can modulate various adipocyte-associated activities including for example, thermogenesis in , adipocytes e.g. brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules recombinant expression vectors , containing PGC-1 nucleic acid molecules host cells into which the expression , vectors have been introduced and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins antigenic peptides and anti-PGC-1 , antibodies. …