Methods for identifying ligands for nuclear hormone receptors
CA 2288978 A1 · Owner: Forman, Barry Marc · Inventors: Evans, Ronald M.; Forman, Barry Marc
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Fatty acids (FAs) and their derivatives are essential cellular metabolites whose concentations must be closely regulated. This implies that regulatory circuits exist which can sense changes in FA levels. Indeed the peroxisome , proliferator activated receptor .alpha. (PPAR.alpha.) regulates lipid homeostasis and is transcriptionally activated by a variety of lipid-like compounds. It remains unclear as to how these structurally-diverse compounds can activate a single receptor. In accordance with the present invention there are provided conformation-based assays which screen activators for their ability to bind to PPARs (i.e. PPAR.alpha. PPAR.delta. and PPAR.gamma.) and induce DNA …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 1, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended April 1, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 1, 2020.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.