Coupling of unmodified proteins to haloacyl or dihaloacyl derivatized polysaccharides for the preparation of protein-polysaccharide vaccines
CA 2288267 A1 · Owner: Lees, Andrew C. · Inventors: Lees, Andrew C.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method for preparing a conjugate, and preferably a protein-polysaccharide conjugate, includes functionalizing a first moiety (e.g. a polysaccharide) with one or more pendant haloacyl groups. Thereafter the functionalized first , moiety is reacted with a second moiety preferably an unmodified protein or a protein to which no thiol groups have been added to form a covalently linked , conjugate. Various different haloacyl reagents can be used in the invention. For example, the haloacyl reagent can be an active ester an anhydride, a , haloacyl chloride, or a haloacyl acid. Specific haloacyl reagents that can be used in the process of the invention include …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 23, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended April 23, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 23, 2020.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.