In vivo use of recombinagenic oligonucleobases to correct genetic lesions in hepatocytes
CA 2288209 A1 · Owner: Steer, Clifford J. · Inventors: Kren, Betsy T.; Bandy-Opadhyay, Paramita T.; Steer, Clifford J.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention concerns compositions and methods for the introduction of specific genetic changes in endogenous genes of the cells of an animal. The genetic changes are effected by oligonucleotides or oligonucleotide derivatives and analogs, which are generally less than about 100 nucleotides in length. The invention provides for macromolecular carriers optionally , incorporating ligands for clathrin coated pit receptors. In one embodiment the ligand is a lactose or galactose and the genetic changes are made in hepatocytes. By means of the invention up to 40 % of the copiies of a target gene have been changed in vitro. Repair of mutant genes having a Crigler- Najjar like …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 30, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended April 30, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 30, 2020.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.