Stereoselective microbial reduction of a racemic tetralone
CA 2287560 C · Owner: Wong, John Wing · Inventors: Morse, Brook Knight; Truesdell, Susan Jane; Wong, John Wing
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to processes for carrying out the following stereoselective microbial reduction of a racemic tetralone: (see formula I), which comprises: contacting a compound of formula (I) with a microorganism or , an, enzyme reduction system capable of accomplishing the subject reduction comprising, an enzyme derived from said microorganism and a co-factor for said enzyme and, incubating the resulting mixture under conditions sufficient to yield the (4R) tetralol of, formula (II) and to leave substantially unreacted the (4S) tetralone of formula (V) or, "chiral tetralone." The chiral tetralone can be used in the synthesis of sertraline. The, subject process further …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 27, 1999 and granted August 19, 2003. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended October 27, 2019.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 27, 2021.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.