Production of functional proteins: balance of shear stress and gravity
CA 2286349 A1 · Owner: Goodwin, Thomas John · Inventors: Hammond, Timothy Grant; Goodwin, Thomas John; Kaysen, James Howard
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-a-hydroxylase which can be used to generate the active form of vitamin D:1,25-diOH vitamin D3. The fibroblast cultures and co-culture of renal cortical cells express the gene for erythropoietin and secrete erythropoietin into the culture supernatant. Other shear stress response genes are also modulated by shear stress such as toxin receptors , megalin and cubulin (gp280). Also provided is a method of treating in-need …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 7, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended April 7, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 7, 2020.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.