1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase iv inhibitory activity

Abstract From the Canadian patent

1-Cycloalkyl-1,8-naphthyridin-4-one derivatives represented by formula (I); pharmacologically acceptable salts or solvates thereof; and a phosphodiesterase IV inhibitor containing any of these as an active ingredient, wherein R1 represents optionally substituted cycloalkyl or optionally substituted heterocycloalkyl; R2 R3, and R4 each independently , represents hydrogen optionally substituted lower alkyl, or halogeno; and X represents NR5R6 or OR7 (wherein R5 and R6 each independently represents hydrogen, optionally substituted lower alkyl optionally substituted , cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl; and R7 represents hydrogen, optionally …