A transgenic model of colon cancer and anal cancer
CA 2284735 A1 · Owner: Wagner, Thomas E. · Inventors: Crish, James F.; Eckert, Richard L.; Wagner, Thomas E.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides human involucrin (hINV) sequences having tissue specific and cell type specific promoter activity. The sequences provided herein direct expression to suprabasal cells of stratifying epithelia. The invention further provides trangenic animals which contain an hINV promoter sequence which directs the expression of human papillomavirus 16 oncogenes. These animals display cervical and epidermal hyperplasias as well as cancer of the trachea, esophagus, colon, epidermis anus/rectum, lymph nodes, spleen and , lung. The animals of the invention provide a useful model for screening potential anti-neoplastic compounds, carcinogens and co-carcinogens for a , …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 24, 1998. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 24, 2018.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 24, 2020.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.